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检测62例慢性肾功能不全患者血清Ⅳ型胶原（CⅣ）和层粘蛋白（LN）水平。结果显示：慢性肾功能不全各期患者血清CⅣ浓度明显高于正常对照者，其增高程度与血清肌酐水平呈显著正相关（r=0．768，P＜0．01）；血清LN浓度也高于正常人，但仅在氮质血症和尿毒症期才有明显差异，LN增高程度也与血清肌酐水平呈显著正相关（r=0.581，P＜0.05）。提示：血清CⅣ、LN浓度变化与临床肾功能损害程度密切相关，检测其水平有助于判断病变程度及预后。
Serum levels of type Ⅳ collagen (C Ⅳ) and laminin (LN) were measured in 62 patients with chronic renal failure. The results showed that serum CⅣ concentration in patients with chronic renal insufficiency was significantly higher than that in controls, and the level of serum CⅣ was positively correlated with serum creatinine (r = 0.768, P <0.01). Serum LN concentration was also high In normal subjects, there was a significant difference only in azotemia and uremia. The increase in LN was also positively correlated with serum creatinine (r = 0.581, P <0.05). It is suggested that the changes of serum CⅣ and LN concentrations are closely related to the degree of clinical renal impairment. To detect the levels of serum CⅣ and LN may be helpful to judge the degree and prognosis of the disease.