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目的探讨VEGF和Survivin联合检测在NSCLC中的诊断价值。方法 48例NSCLC患者分别经VEGF、survivin及VEFG和Survivin联合检测,比较三种检测方法的敏感性、特异性、阳性预测值及阴性预测值。结果联合检测敏感性明显提高,与单用VEFG和Survivin检测比较有显著差异(p<0.05)。结论 NSCLC恶性胸腔积液中VEGF和Survivin均有表达,VEGF和Survivin两者联合检测可提高诊断NSCLC恶性胸腔积液的敏感性。
Objective To investigate the diagnostic value of combined detection of VEGF and Survivin in NSCLC. Methods 48 patients with NSCLC were detected by VEGF, survivin, VEFG and Survivin respectively. The sensitivity, specificity, positive predictive value and negative predictive value of the three methods were compared. Results The sensitivity of combined detection was significantly higher than that of VEFG alone or Survivin alone (p <0.05). Conclusions Both VEGF and Survivin are expressed in malignant pleural effusion of NSCLC. Combined detection of VEGF and Survivin may improve the sensitivity of diagnosis of malignant pleural effusion in NSCLC.