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血吸虫病患者肝脏的组织病理变化可引起某些血清酶的变化,如天冬氨酸转氨酶(AST)和碱性磷酸酶(ALP)活力升高。但这些酶对评价不同期血吸虫病肝脏受损程度的作用不大。作者应用3种其他肝源性血清酶—单胺氧化酶(MAO)、γ-谷氨酰转肽酶(GGT)和谷氨酸脱氢酶(GDH)试验,评价早期和晚期血吸虫病肝脏受损情况。并与常规肝功能试验包括AST、丙氨酸转氨酶(ALT)和ALP进行比较。试验分3组进行。观察对象均为男性埃及人。第1组25例,为无并发症的早期曼氏血吸虫病人。第2组26例,为感染较重伴有肝脾肿大和腹水的晚期病人。第3组21例,为无血吸虫感染的对照组,其年龄、体重和社会经济地位与前两组相仿。
Histopathological changes in the liver of patients with schistosomiasis can cause changes in certain serum enzymes, such as increased activity of aspartate aminotransferase (AST) and alkaline phosphatase (ALP). However, these enzymes have little effect on the assessment of liver damage in different stages of schistosomiasis. The authors used three other liver-derived serum enzyme monoamine oxidase (MAO), γ-glutamyl transpeptidase (GGT) and glutamate dehydrogenase (GDH) test to assess the early and advanced liver damage in schistosomiasis. And compared with routine liver function tests including AST, alanine aminotransferase (ALT) and ALP. The experiment was divided into 3 groups. Observers are male Egyptians. The first group of 25 cases, without complications of early man’s schistosomiasis. The second group of 26 cases, with severe infection with hepatosplenomegaly and ascites in advanced patients. Group 3 21 cases without schistosome infection control group, its age, weight and socioeconomic status similar to the previous two groups.