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目的 :探讨p53基因、细胞增殖抗原Ki 67在下咽癌临床分期、淋巴结转移及预后中的作用。方法 :应用免疫组织化学LASB法检测 84例下咽鳞癌石蜡标本 ,研究p53蛋白、细胞增殖抗原Ki 67的表达并与临床因素进行统计分析。结果 :下咽癌中p53阳性率为 52 4 % ;Ki 67标示率为 0～ 7% ,平均为 10 63% ,中位数为 7 2 5%。淋巴结转移组与非转移组Ki 67表达差异有显著性 (P <0 0 1)。结论 :p53基因表达可作为下咽癌诊断的标志物之一 ,Ki 67可作为临床预测下咽癌颈淋巴结转移及预后的重要参考指标。
Objective: To investigate the role of p53 gene and Ki 67 in the clinical stage, lymph node metastasis and prognosis of hypopharyngeal carcinoma. Methods: Immunohistochemical LASB method was used to detect the paraffin specimens of 84 cases of hypopharyngeal squamous cell carcinoma, to study the expression of p53 protein and Ki67, and to make statistical analysis with clinical factors. Results: The positive rate of p53 in hypopharyngeal carcinoma was 52 4%. The Ki 67 labeling rate was 0-7% with an average of 10 63% with a median of 72.5%. The expression of Ki 67 in lymph node metastasis group and non-metastasis group was significantly different (P <0.01). Conclusion: The expression of p53 gene may be one of the markers for the diagnosis of hypopharyngeal carcinoma. Ki 67 may be used as an important reference for clinically predicting cervical lymph node metastasis and prognosis of.