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近年来,可能由于对恶性疾病更多地使用细胞毒性药,这些药的各种副作用及毒性更属常见,其毒性引起的症状来势猛而严重以至掩盖了某些次要的功能障碍。作者在用争光霉素治疗的食管恶性肿瘤病例中有1例发生了味觉障碍而在停药后恢复。有鉴于此,乃决定研究争光霉素疗法病例的味觉。作者检查50例用争光霉素治疗的晚期恶性病者的味觉。在化疗开始前用电味觉计测定味觉阈,以后的10周内每周用同样方法在同样环境下复测一次。为排除其他因素所引起的味觉障碍,凡有以下问题者不作为检查对象:重度嗜烟、嗜酒者,有脑神经缺陷,慢性中耳疾病或中耳术后,显著
In recent years, due to the increased use of cytotoxic drugs for malignant diseases, the various side effects and toxicities of these drugs have become even more common, and the toxicity-induced symptoms are so violent that they mask some secondary dysfunction. One of the patients with esophageal malignancy treated with bleomycin had dysgeusia and resumed after withdrawal. In view of this, it is decided to study the taste of bleomycin-treated cases. The authors examined the taste of 50 patients with advanced malignancies treated with bleomycin. Before the start of chemotherapy, the taste threshold was determined with the electric taste meter, and the same method was used for the same test again in the next 10 weeks. To exclude other factors caused by taste disorders, who have the following questions are not as subjects: severe addictions, alcoholics, brain defects, chronic middle ear disease or middle ear surgery, significant