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目的探讨高频振荡通气联合前列地尔治疗新生儿持续肺动脉高压的效果。方法将100例持续肺动脉高压新生儿,随机分为对照组和观察组,每组50例。对照组给予常规机械通气治疗,观察组则给予高频振荡通气联合前列地尔治疗措施。观察记录治疗前、后两组患者的血气分析结果及肺动脉收缩压(PASP)测量结果、呼吸机使用时间及治疗效果等。结果治疗后,观察组p H值、动脉氧分压(Pa O2)、血氧饱和度(Sa O2)明显升高,动脉二氧化碳分压(Pa CO2)、肺动脉压(PASP)指标明显降低(P<0.05),且效果明显好于对照组(P<0.05);另外,观察组呼吸机使用时间明显短于对照组(P<0.05);观察组治疗总有效率为91.7%,明显好于对照组的83.3%(P<0.05)。结论高频振荡通气联合前列地尔治疗新生儿持续肺动脉高压临床效果显著,值得进一步在临床中推广应用。
Objective To investigate the effect of high-frequency oscillatory ventilation combined with alprostadil in the treatment of persistent pulmonary hypertension in neonates. Methods 100 newborns with persistent pulmonary hypertension were randomly divided into control group and observation group, 50 cases in each group. The control group was given routine mechanical ventilation, while the observation group was given high-frequency oscillatory ventilation combined with alprostadil treatment. The results of blood gas analysis and PASP measurement, ventilator use time and treatment effect were recorded and recorded before and after treatment. Results After treatment, the values of p H, Pa O2 and Sa O2 in the observation group were significantly increased, while the Pa CO2 and PASP indexes in the observation group were significantly decreased (P 0.05), and the effect was significantly better than the control group (P <0.05); In addition, the use of ventilator in the observation group was significantly shorter than the control group (P <0.05); the total effective rate was 91.7% 83.3% of the group (P <0.05). Conclusion High-frequency oscillatory ventilation combined with alprostadil for the treatment of neonatal persistent pulmonary hypertension has a significant clinical effect and is worth further promotion and clinical application.