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Spitz肿瘤是一组发生于青年人,主要由梭形及上皮样肿瘤细胞组成的黑色素细胞肿瘤。Spitz黑色素肿瘤包括良性的Spitz痣,恶性潜能未定的非典型Spitz肿瘤和Spitz样恶性黑色素瘤。目前通过皮肤病理学形态上鉴别惰性病变或是侵袭性致命肿瘤仍是一个难题。有研究表明,Spitz肿瘤存在包括ALK基因融合在内的多种基因融合,且这些基因融合肿瘤具有特定的临床病理特点。为此作者对17例伴有
Spitz tumor is a group of melanocytic tumors that occur in young people and consist mainly of spindle and epithelioid tumor cells. Spitz melanoma tumors include benign Spitz neoplasms, atypical malignant tumors of atypical Spitz and Spitz-like malignant melanoma. It is still a challenge to identify idiopathic or aggressive, fatal tumors morphologically on the skin pathology. Some studies have shown that Spitz tumor exists including ALK gene fusion, including a variety of gene fusion, and these gene fusion tumors have a specific clinicopathological features. For this reason the author of 17 cases