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P-糖蛋白介导的药物外排被普遍认为是导致肿瘤产生多药耐药的重要因素。简介P-糖蛋白及其抑制剂发展历程,重点阐述近年来世界各国科学家开展逆转肿瘤耐药的P-糖蛋白抑制剂研发的新策略和新思路,探讨现阶段P-糖蛋白抑制剂的发展趋势。
P-glycoprotein-mediated drug efflux is generally considered to be an important factor in the multidrug resistance of tumors. Brief introduction to the development of P-glycoprotein and its inhibitors, focusing on the new strategies and new ideas for the development of P-glycoprotein inhibitors to reverse tumor drug resistance in various countries in the world in recent years, and to explore the current development of P-glycoprotein inhibitors trend.