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糖尿病肾病(DN)是糖尿病(DM)最严重的并发症之一,又是终末期肾病主要原因。临床糖尿病一旦发生,肾脏损害发展速度迅速增快。美国疾病预防控制中心统计资料显示,DN患者占DM的67%以上,欧美国家慢性肾功能衰竭(CRF)透析患者中心DN占43%左右,DN是DM患者终末期肾衰竭(ERDS)死亡的主要原因[1]。系膜区细胞外基
Diabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus (DM) and is a major cause of end-stage renal disease. Once clinical diabetes occurs, the development of kidney damage rapidly increases. Statistics from the CDC show that DN patients account for more than 67% of DMs, and about 43% of central DN patients in chronic dialysis patients with chronic renal failure (CRF) in Europe and the United States are DN. DN is the major cause of death in end-stage renal failure (ERDS) in DM patients Reason [1]. Mesangial cell extracellular base