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吞噬细胞表面膜糖蛋白与糖脂所含的寡糖链,可与凝集素产生糖特异性联结.由于凝集素与糖的结合是多价的,极易在吞噬细胞和其他细胞之间形成桥,这是非免疫性吞噬现象的机理之一.例如伴刀豆蛋白A(ConA)所介导的巨噬细胞对细菌的糖特异性吸附,以及ConA使鼠腹腔巨噬细胞与鼠红细胞形成稳定玫瑰花结的实验.ConA、WGA(麦胚凝集素)、PNA(花生凝集素)等还具有介导巨噬细胞和肿瘤细胞结合的能力,这些发现提示了对肿瘤监视机制的一种新形式,这种机制可由体内的凝集素介导.
Phagocytic cell surface glycoprotein and glycolipids contained in the oligosaccharide chain, with the lectin to produce sugar-specific binding.Because the binding of lectin and sugar is multivalent, easily in the phagocyte and other cells form a bridge , Which is one of the mechanisms of non-immune phagocytosis.For example, ConA-mediated macrophage-specific sugar adsorption to bacteria, and ConA to rat peritoneal macrophages and rat erythrocytes to form a stable rose The experiments of floral knotting, such as CONA, WGA (Wheat Germ Agglutinin), PNA (Peanut Lectin) and the like, also have the ability to mediate the binding of macrophages to tumor cells. These findings suggest a new form of tumor surveillance mechanism, This mechanism can be mediated by lectins in the body.