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目的：观察硒对人肺腺癌细胞系ＳＰＣ－ＡⅠ生长和ＤＮＡ、ＲＮＡ以及蛋白质合成的影响。方法：在一定浓度的人肺腺癌细胞系ＳＰＣ－ＡⅠ中加入不同浓度的亚硒酸钠，用苔盼蓝染色及同位素掺入法观察和研究其变化，对实验结果进行统计处理。结果：当亚硒酸钠浓度在０．５μｇ／ｍｌ时，能明显刺激肿瘤细胞增殖和ＤＮＡ、ＲＮＡ以及蛋白质合成；但当亚硒酸钠浓度增加至１．０μｇ／ｍｌ和２．０μｇ／ｍｌ时，肿瘤细胞明显受到抑制，同时ＤＮＡ、ＲＮＡ和蛋白质合成也明显下降。结论：硒对人肺癌细胞生长和大分子生物合成有双向作用。
Objective: To observe the effects of selenium on the growth of human lung adenocarcinoma cell line SPC-AI and DNA, RNA and protein synthesis. METHODS: Sodium selenite with different concentrations was added to certain concentrations of human lung adenocarcinoma cell line SPC-AI. The changes were observed and studied by typan blue staining and isotope incorporation. The experimental results were statistically processed. Results: When the concentration of sodium selenite was 0.5μg/ml, it could obviously stimulate the proliferation of tumor cells and DNA, RNA and protein synthesis; but when the concentration of sodium selenite increased to 1.0μg/ml and 2.0μg/ml At that time, tumor cells were significantly inhibited, and DNA, RNA, and protein synthesis also decreased significantly. Conclusion: Selenium has two-way effect on the growth of human lung cancer cells and biosynthesis of macromolecules.