,Historic perspectives and recent advances in major animal models of hypertension

• 作 者: Zhong-jie SUN Zhong-e ZHANG
• 机 构: Departments of Medicine and Physiology & Functional Genomics,College of Medicine,University of Flori
• 出 处: 中国药理学报（英文版）
• 发表日期: 2005年3期
• 关键词: spontaneous hypertension cold-induced hypertension DOCA-salt-induced hyper tensi

Hypertension and related cardiovascular diseases are the leading causes of death in many countries. The etiology of human essential hypertension is largely unknown. It is highly likely that hypertension is a complex and multifactorial disease resulting from the interaction of multiple genetic and environmental factors.Animal models of hypertension have been proved to be useful to study the pathogenesis of, and to find a new therapy for, hypertension. The aim of this article is to briefly review the most widely used rodent models of experimental hypertension,including history and recent advances. These models are classified as genetically-induced, environmentally-induced, pharmacologically-induced, and renalinduced hypertension according to the way of induction; the typical representatives of each of these major types of experimental hypertension are spontaneous hypertension, cold-induced hypertension, DOCA-salt-induced hypertension, and renal-induced hypertension, respectively. The processes of induction of hypertension, possible pathogenesis, characteristics, advantages, and limitations of these animal models are reviewed. In addition, the clinical implications of the above experimental models of hypertension are addressed.