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1972年吸入类皮质醇治疗哮喘,取得了很大的进展,并可避免口服类皮质醇产生的副作用。作者对19例哮喘儿童(男14,女5)进行研究,年龄10～15岁;骨骼年龄8.1～14.9岁。其中12例吸入二丙酸倍氯米松治疗,300～1,000μg/d,分2～4次给予;7例为对照组。19例在3个月内都没有口服过类皮质醇。从午夜0～6点,每隔20分钟抽血1次,使用放射免疫方法测定血浆中皮质醇的含量。发现治疗组和对照组两组早晨6点血浆中皮质醇的水平比午夜零点
Cortisol inhalation in 1972 in the treatment of asthma, made great progress, and can avoid the side effects of oral cortisol. The study of 19 children with asthma (male 14, female 5) were studied, aged 10 to 15 years; skeletal age 8.1 to 14.9 years old. Among them, 12 cases were treated with beclomethasone dipropionate, 300 ~ 1,000μg / d, and were given 2 ~ 4 times; 7 cases were control group. Nineteen patients had no oral cortisol orally within 3 months. From midnight 0 to 6 points, blood was drawn every 20 minutes, and radioimmunoassay was used to determine plasma cortisol levels. The plasma cortisol levels at 6 am in the treatment and control groups were found to be at 0 o’clock midnight