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目的观察帕米膦酸二钠（博宁）对癌症骨痛的临床疗效。方法２０例晚期恶性肿瘤骨痛患者静脉点滴博宁９０ｍｇ一次，部分病例合并化疗（ｎ＝７）或内照射治疗（ｎ＝７）。结果博宁对骨痛的总有效率为８５．０％（１７／２０），合并化疗、１５３Ｓｍ－ＥＤＴＭＰ治疗和单纯博宁治疗的有效率分别为１００％、８５．７％和６６．７％，无明显毒副作用。结论博宁能有效地缓解癌症骨痛和活动功能障碍，提高患者的生活质量，其与化疗、１５３Ｓｍ－ＥＤＴＭＰ内照射治疗联用，疗效更好。
Objective To observe the clinical efficacy of pamidronate disodium (Bonin) on cancer bone pain. Methods 20 patients with advanced malignant bone pain were intravenously intravenously administered with 90 mg of Boning, and some patients were treated with chemotherapy (n=7) or internal irradiation (n=7). Results The total effective rate of bone pain in Boning was 85.0% (17/20). The effective rates of combined chemotherapy, 153Sm-EDTMP treatment and simple Boning treatment were 100%, 85.7% and 66.7% respectively. , No obvious side effects. Conclusion Bonin can effectively relieve cancer bone pain and activity dysfunction and improve the patient’s quality of life. It is better combined with chemotherapy and 153Sm-EDTMP internal irradiation treatment.