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长期以来,抗生素过度使用或滥用导致细菌耐药性不断增强,已成为严重的公共卫生问题[1]。噬菌体是感染细菌、真菌、藻类、放线菌或螺旋体等微生物的病毒的总称,个体微小,不具有完整细胞结构,只含有单一核酸。它在细菌细胞中利用细菌的物质系统来实现其自身的生长和增殖,从而使细菌裂解,可有效控制疾病的发生。因此近年来噬菌体作为一种新的治疗制剂受到广泛关注[2]噬菌体对细菌的裂解有专一性,这使其不能广泛
For a long time, overuse or abuse of antibiotics has led to the increase of bacterial resistance, which has become a serious public health problem [1]. Bacteriophages are the general term for viruses that infect microorganisms such as bacteria, fungi, algae, actinomycetes or spirochetes. Individuals are tiny, have no intact cell structure, and contain only a single nucleic acid. It uses bacteria in the bacterial cells in the material system to achieve its own growth and proliferation, so that bacterial lysis, can effectively control the disease. In recent years, therefore, bacteriophage has received widespread attention as a new therapeutic agent. [2] Bacteriophages are specific for bacterial lysis, rendering them inoperable