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目的:在胰岛素强化治疗中,来得时(甘精胰岛素)与NPH(中效胰岛素)的疗效对比。方法:按一定标准选择T2DM患者98例,随机分为两组使用来得时与NPH强化治疗。监测每日7点血糖,记录低血糖事件,12周HbA1c,体重等。结果:来得时组在每个点的血糖控制均优于NPH组,尤其空腹血糖控制更加理想。HbA1c达标率高,与NPH组比减少低血糖风险。结论:T2DM患者使用来得时较NPH更安全有效。
OBJECTIVE: To compare the efficacy of insulin glargine (NPG) with NPH (insulin of intermediate effect) in insulin intensive therapy. Methods: A total of 98 patients with T2DM were selected according to a certain standard and were randomly divided into two groups to be treated with NPH. Monitoring daily 7:00 glucose, hypoglycemic events recorded, 12 weeks HbA1c, weight and so on. Results: The control group had better blood glucose control at each point than the NPH group, especially the fasting blood glucose control was more ideal. HbA1c compliance rate, with the NPH group to reduce the risk of hypoglycemia. Conclusions: T2DM patients are safer and more effective than NPH when used.