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A 78-year-old man got lumbago, edema for 9 years and cough, expectoration for 30 years, and was hospitalized with progressive severity of the symptoms for 5 days. He was diagnosed as coronary heart disease,chronic bronchitis, diabetes, and treated with anti-infection and symptomatic therapy. Several days later, he received allopurinol 100mg twice daily by mouth,because of high serum concentrations of uric acid. The patient developed chill, hyperpyrexia and fatigue after 9 consecutive days of administration. Physical examination revealed a temperature of 39.6℃ and lab findings included WBC 0.8×109/L with neutrophil 0.4. Aplastic anemia was approved on bone marrow puncture. Allopurinol was withdrawn immediately and the the symptoms were resolved.
A 78-year-old man got lumbago, edema for 9 years and cough, expectoration for 30 years, and was hospitalized with progressive severity of the symptoms for 5 days. He was diagnosed as coronary heart disease, chronic bronchitis, diabetes, and treated Several days later, he received allopurinol 100mg twice daily by mouth, because of high serum concentrations of uric acid. The patient developed chill, hyperpyrexia and fatigue after 9 consecutive days of administration. Physical examination revealed a temperature of 39.6 ° C and lab findings included WBC 0.8 × 10 9 / L with neutrophil 0.4. Aplastic anemia was approved on bone marrow puncture. Allopurinol was withdrawn immediately and the symptoms were resolved.