Associations between low-density lipoprotein cholesterol and haemorrhagic stroke

• 作 者: Yun-Yan XIE Shi-Meng LIU Qian ZHANG Yu JIA Jian-Ping DING
• 机 构: Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing,China;Department of Neuro
• 出 处: 老年心脏病学杂志（英文版）
• 发表日期: 2021年3期

OBJECTIVE To investigate the associations between the blood concentrations of low-density lipoprotein cholesterol(LDL-C)and the clinical features of haemorrhagic stroke.METHODS This study analysed the data from patients with acute haemorrhagic stroke at a comprehensive stroke centre from 2013 to 2018.Patients were stratified into three groups according to their baseline LDL-C levels:＜70,70 to＜100 and≥100 mg/dL.We used multivariate logistic regression models to analyse the associations between LDL-C and the risks of having severe neurological deficits(National Institute Health Stroke Scale[NIHSS]scores≥15)and unfavourable outcomes(modified Rankin Scale[mRS]scores＞2)at discharge.RESULTS Six-hundred and six patients were analysed.Their median age was 58 years.Among the patients,75(12％)patients had LDL-C levels＜70 mg/dL,194(32％)patients had LDL-C levels between 70 to＜100 mg/dL and the other 337(56％)patients had LDL-C levels≥100 mg/dL.Patients with higher LDL-C levels were less likely to suffer severe neurological deficits(LDL-C:70 to＜100 vs.＜70 mg/dL,adjusted odds ratio[OR]:0.29,95％CI:0.15-0.57;LDL-C:2 100 vs.＜70 mg/dL,adjusted OR = 0.27,95％CI:0.15-0.51)and to have unfavourable outcomes at discharge(LDL-C:70 to＜100 vs.＜70 mg/dL,adjusted OR = 0.50,95％CI:0.29-0.87 and LDL-C:2100 vs.＜70 mg/dL,adjusted OR = 0.46,95％CI:0.28-0.78).CONCLUSIONS An LDL-C level＜70 mg/dL was independently associated with severe neurological deficits of haemorrhagic stroke and may increase the risks of unfavourable outcomes at discharge.