IN VITRO ANALYSIS OF τ PHOSPHORYLATION SITES AND ITS BIOLOGICAL ACTIVITY

• 作 者: 王建枝 王小川 刘蓉 王群 Inge Grundke Iqb
• 机 构: TongjiMedicalCollege,NYSInstituteforBasicResearchinDevelopmentalDisabilities
• 出 处: 中国医学科学杂志：英文版
• 发表日期: 2002年1期
• 关键词: Τ蛋白 磷酸化 生物学活性 蛋白激酶 体外分析 早老性痴呆 AD g protein phosphorylation Alzheimer disease pro
• 基金项目: 国家自然科学基金，国家重点基础研究发展计划(973计划)，National Institute of Health in USA

Objective.To explore the association between the abnormal phosphorylation sites found in Alzheimer disease (AD) τ and the inhibition of its biological activity. Methods.Ultracentrifugation,chromatography,manual Edman degradation and autosequence technique