【摘 要】
:
目的 探讨青海地区结核分枝杆菌(MTB)对利福平(RFP)、氟喹诺酮类药物、异烟肼(INH)等的耐受情况及与其相对应的rpoB、gyrA、katG突变基因关系.方法 选择PCR和DNA测序法检测分析结核
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目的 探讨青海地区结核分枝杆菌(MTB)对利福平(RFP)、氟喹诺酮类药物、异烟肼(INH)等的耐受情况及与其相对应的rpoB、gyrA、katG突变基因关系.方法 选择PCR和DNA测序法检测分析结核分枝杆菌分离株gyrA、katG以及rpoB的基因序列.结果 经检测,耐INH菌株中katG基因突变率为70.9%,耐RFP菌株中rpoB基因突变率为83.33%,耐氟喹诺酮类药物菌株中gyrA基因突变率为77.27%.katG最常见的突变形式为Ser315Thr(86.67%),rpoB最常见的突变形式为
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