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糖皮质激素(glucocorticoid,GC)因具有抗炎、抑制免疫反应、调节能量代谢和细胞增殖凋亡等作用而广泛使用于临床。作为非编码RNA,内源性miRNA通过影响靶基因的表达水平在机体发育和疾病发生中发挥广泛的调控作用。目前研究发现,糖皮质激素能通过糖皮质激素受体(glucocorticoid receptor,GR)介导调节miRNA的表达,而miRNA也能通过影响糖皮质激素受体的表达水平调节细胞对糖皮质激素的反应性。在许多疾病模型中,miRNA和糖皮质激素受体之间通过密切互作关系共同影响疾病的发生发展。
Glucocorticoid (GC) is widely used in clinic because of its anti-inflammatory, anti-inflammatory reaction, regulation of energy metabolism and cell proliferation and apoptosis. As a non-coding RNA, endogenous miRNAs play a broad regulatory role in body development and disease by affecting the expression level of a target gene. The current study found that glucocorticoid can regulate the expression of miRNA through the glucocorticoid receptor (GR), and miRNA can regulate the glucocorticoid responsiveness by affecting the expression of glucocorticoid receptor . In many disease models, the close interaction between miRNA and glucocorticoid receptors affects the development of the disease.