论文部分内容阅读
目的探讨脓毒症患者不同血糖水平对肝脏功能的影响。方法采用回顾性队列研究的方法纳入2014年3月至2015年1月间的93例脓毒症患者,根据入重症医学科(ICU)当天最大血糖值是否超过10mmol/L进行分组,进一步评估两组患者入ICU后的血常规、肝肾功能和凝血功能。结果正常糖组(血糖≤10mmol/L)的患者相较于高糖状态组(血糖>10mmol/L)的患者而言,入ICU后第1天的血小板计数更低,总胆红素水平和直接胆红素水平更高,高密度脂蛋白胆固醇和低密度脂蛋白胆固醇较低,且凝血酶原时间、国际标准化比值和活化部分凝血活酶时间延长,抗凝血酶Ⅲ更少(P均<0.05)。所有检查指标在入ICU后的第7天两组差异无统计学意义(P>0.05)。结论在脓毒症患者中,血糖正常的患者可能存在程度更重的肝脏功能损伤。
Objective To investigate the effects of different blood glucose levels in patients with sepsis on liver function. Methods A retrospective cohort study was conducted in 93 sepsis patients from March 2014 to January 2015. The patients were divided into two groups according to whether the maximum blood glucose level exceeded 10 mmol / L on the day of intensive care unit (ICU) Patients after ICU into the blood routine, liver and kidney function and coagulation. Results In patients with normal glucose group (blood glucose ≤10mmol / L), the first day after admission into the ICU, the platelet count was lower and the total bilirubin level was significantly lower than that in the high glucose group (blood glucose> 10mmol / L) Direct bilirubin levels higher, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol lower, and prothrombin time, the international standardization ratio and activated partial thromboplastin time, antithrombin Ⅲ less (P <0.05). There was no significant difference between the two groups (P> 0.05) on the 7th day after all the indexes were included in the ICU. Conclusion In patients with sepsis, patients with normal blood glucose may have a greater degree of liver dysfunction.