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目的探讨2型糖尿病(T2DM)患者血清糖化白蛋白(GA)水平与颈动脉斑块之间的相关性。方法 156例住院的T2DM患者,所有患者均行颈动脉超声检查,测量颈动脉内中膜厚度(IMT),并检测GA及相关生化指标,根据有无颈动脉斑块分为A组(无颈动脉斑块者,84例)和B组(有颈动脉斑块者,72例),并进行相关统计学分析。结果 B组的GA水平显著高于A组,GA与IMT之间呈显著正相关(P<0.05)。Logistic多元回归分析表明,GA及糖化血红蛋白是颈动脉斑块的独立危险因素(P<0.05)。结论 GA与T2DM患者的颈动脉斑块之间关系密切,可以作为预测T2DM大血管病变的临床指标。
Objective To investigate the correlation between serum level of glycosylated albumin (GA) and carotid artery plaque in type 2 diabetes mellitus (T2DM). Methods A total of 156 hospitalized patients with T2DM were enrolled in this study. All patients underwent carotid ultrasonography to measure carotid intima - media thickness (IMT) and to detect GA and related biochemical markers. Patients were divided into group A Arterial plaque, 84 cases) and group B (carotid plaque, 72 cases), and related statistical analysis. Results The GA level in group B was significantly higher than that in group A, and there was a significant positive correlation between GA and IMT (P <0.05). Logistic multiple regression analysis showed that GA and HbA1c were independent risk factors for carotid artery plaque (P <0.05). Conclusion GA is closely related to carotid plaque in patients with T2DM, which may be used as a clinical index in predicting macrovascular complications of T2DM.