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目的:观察稳心颗粒联合美托洛尔治疗室性心律失常的临床疗效及不良反应。方法:选择室性心律失常116例,随机分为观察组和对照组各58例。对照组采用口服美托洛尔治疗,每次12.5～25mg,每天2次。观察组在对照组基础上,增加稳心颗粒治疗,每次9g,每天3次。均4周为1个疗程,观察两组治疗前后临床症状、心电图改善情况及不良反应。结果:观察组临床总有效56例(96.6%),对照组43例(74.1%);两组比较,差异显著(P<0.05)。观察组心电图总改善55例(94.3%),对照组45例(77.6%);两组比较,差异显著(P<0.05)。两组均未发生严重不良反应。结论:稳心颗粒联合美托洛尔治疗室性心律失常较单用美托洛尔疗效好,且安全。
Objective: To observe the clinical efficacy and adverse reactions of Wenxin Granule combined with metoprolol in the treatment of ventricular arrhythmia. Methods: One hundred and sixty-six patients with ventricular arrhythmia were randomly divided into observation group (58 cases) and control group (58 cases). Control group with oral metoprolol treatment, each 12.5 ~ 25mg, 2 times a day. Observation group in the control group, based on the increase of Wenxin particles treatment, each 9g, 3 times a day. 4 weeks for a course of treatment before and after treatment to observe the clinical symptoms, ECG improvement and adverse reactions. Results: The total effective rate of observation group was 56 cases (96.6%) and that of control group (43.1%). There was significant difference between the two groups (P <0.05). In the observation group, 55 cases (94.3%) improved electrocardiogram and 45 cases (77.6%) in the control group. There was significant difference between the two groups (P <0.05). No serious adverse reactions occurred in both groups. Conclusion: Wenxin granule combined with Metoprolol has better curative effect than metoprolol alone in the treatment of ventricular arrhythmia, and is safe.