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非类固醇抗炎药与胃溃疡形成二者之间的关系早已被充分认识。在服用这类同一药物情况下,类风湿关节炎病人比其它类型关节炎病人发生胃溃疡的危险性高。表皮生长因子是一种分泌入唾液的多肽,并可存在于胃液中。它能保护胃粘膜免受阿司匹林所致的损伤,并可刺激细胞增生,故可促进粘膜溃疡的愈合。类风湿病病人的唾液腺好发病变,故作者极想知道这是否会影响表皮生长因子的生成,从而影响胃粘膜的防御功能和对损伤的反应。为此,作者检测了类风湿病病人的唾液腺分泌表皮生长因子的情况,以及评价干燥综合征对这种因子分泌的影响。病人和方法研究对象分4组:①组类风湿关节炎20例,②组伴有干燥综合征的类风湿关节炎9例,
The relationship between non-steroidal anti-inflammatory drugs and gastric ulcer formation has long been well understood. Patients taking rheumatoid arthritis have a higher risk of developing gastric ulcers than other types of arthritis patients taking the same medication. Epidermal growth factor is a polypeptide that is secreted into the saliva and can reside in the gastric juice. It can protect the gastric mucosa from aspirin-induced damage and can stimulate cell proliferation, it can promote mucosal ulcer healing. Salivary gland patients with rheumatoid disease lesions, so the author very much wondered whether this will affect the formation of epidermal growth factor, thus affecting the gastric mucosal defense and damage to the response. For this reason, the authors examined the secretion of epidermal growth factor (EGF) from the salivary gland of patients with rheumatoid and evaluated the effects of Sjogren’s syndrome on the secretion of this factor. Patients and methods were divided into 4 groups: ① group of rheumatoid arthritis in 20 cases, ② group of 9 cases with rheumatoid arthritis syndrome,