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为了观察FAB分型与骨髓造血功能测定值之间的相互关系,作者总结了1983年1—9月共43例骨髓增生异常综合征(MDS)病人的研究结果。病人中难治性贫血(RA)9例,原发性铁粒幼细胞性贫血(ISA)15例,原始细胞过多性难治性贫血(RAEB)9例,慢性粒单细胞白血病(CMML)4例、转化型RAEB(RAEBT)2例、原发性大红细胞增多症(IM)4例。除个别亚型外多数亚型的粒细胞、网织红细胞、单核细胞、血小板均倾向于减少。骨髓幼稚细胞数量变动范围很大,各亚型原始细胞数值和铁粒幼细胞数值的高低主要是由该亚型的定义而决定的。红细胞生成异常的表现见于所有亚型。43例中有7例的表现既可分入这一亚型,亦可分入另一亚型。除CMML外,所有亚型的大多数病人红细胞集落形成均低于正常范围。各亚型的CFU-GM集落数无明显
In order to observe the correlation between FAB typing and bone marrow hematopoiesis, the authors summarized the results of 43 patients with myelodysplastic syndrome (MDS) from January 1983 to September 1983. 9 cases of refractory anemia (RA), 15 cases of primary ironblastic anemia (ISA), 9 cases of primitive refractory anemia (RAEB), 8 cases of chronic myelomonocytic leukemia (CMML) 4 cases, 2 cases of transformed RAEBT (RAEBT), 4 cases of primary polycythemia (IM). In addition to individual subtypes most subtypes of granulocytes, reticulocytes, monocytes, platelets tend to reduce. The number of naïve cells in bone marrow varies widely, and the numbers of primary cells and the number of blast cells in each subtype are mainly determined by the definition of this subtype. The manifestations of abnormal erythropoiesis are found in all subtypes. Seven of the 43 cases were either subdivided into either subtype or subtype. With the exception of CMML, most patients in all subtypes had erythrocyte colony formation below the normal range. The number of CFU-GM colonies in each subtype was not significant