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目的:探讨在长方案降调节体外受精-胚胎移植中,不同种类FSH在临床使用中效果差别。方法:回顾分析2009年8月~2010年2月在华中科技大学同济医学院附属同济医院生殖中心首次接受体外受精-胚胎移植(IVF/ICSI-ET)助孕术的病例共875个周期的临床指标。根据所用FSH不同分为3组:A组(果纳芬组),B组(普利康组),C组(福特蒙组)。比较各组获卵数、MⅡ卵数、2倍体受精卵数、获得胚胎数、FSH时间、FSH量、妊娠率是否有差异。结果:C组获卵数、MⅡ卵数、2倍体受精卵数、获得胚胎数明显少于A、B组,FSH量明显多于A、B组,有统计学差异。C组总妊娠率、临床妊娠率、持续妊娠率比A、B组高,无统计学差异。移植取消率C组最低,无统计学差异。OHSS发生率C组明显低于A、B组,有统计学差异。结论:rFSH较hp-uFSH获卵更多,但易导致OHSS发生率升高。各种FSH妊娠率无统计学差异。
OBJECTIVE: To explore the differences in the clinical effects of different types of FSH in long-term regimen of IVF-ET. Methods: A total of 875 cycles of in vitro fertilization-embryo transfer (IVF / ICSI-ET) fertilization in the Reproductive Center of Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from August 2009 to February 2010 were retrospectively analyzed. index. Divided into three groups according to different FSH used: A group (fruit satisfied group), B group (Pulican group), C group (Futeng Meng group). The number of oocytes, the number of M Ⅱ oocytes, the number of fertilized eggs in 2 ploidy, the number of embryos obtained, the time of FSH, the amount of FSH and the pregnancy rate were compared. Results: The numbers of oocytes, M Ⅱ oocytes and diploid fertilized eggs in group C were significantly lower than those in groups A and B, and the number of FSH was significantly higher than that in groups A and B. There was a significant difference. The total pregnancy rate, clinical pregnancy rate and continuous pregnancy rate in group C were higher than those in group A and B, with no significant difference. The rate of transplant cancellation was the lowest in group C, with no significant difference. The incidence of OHSS in group C was significantly lower than that in group A and group B, with statistical difference. Conclusion: rFSH ova more eggs than hp-uFSH, but easily lead to an increased incidence of OHSS. The pregnancy rate of various FSH no significant difference.