论文部分内容阅读
作者报道61例临床怀疑合并深部霉菌病的血液疾患患者的诊断依据,分离菌和治疗效果,临床均经静脉输注抗霉菌药物治疗。疑合并深部霉菌病的依据为抗生素无效性发热,胸部x 线检查异常及临床标本检出霉菌。共分3组,包括解剖时见与未见深部霉菌病,分别为22例和12例及未解剖者27例。并以13例未用抗霉菌药物治疗,解剖时发现深部霉菌病者作对照组。抗霉菌药物治疗为静脉内连续用抗霉菌药一周以上,每日用量为两性霉素乙(AMPH)6mg以上,双氯苯咪唑(MCZ)>400mg,氟康唑(FCZ)>200mg,原发疾患为急、慢性白血病37例,恶性淋巴瘤12例,多发性骨髓瘤5例,再障贫血2例,其他5例。
The authors report 61 cases of clinical suspicion of deep mycosis in patients with blood diseases based on the diagnosis, isolation of bacteria and the treatment effect, clinically intravenous infusion of anti-fungal drug treatment. Suspected merger of deep mycosis based on ineffective antibiotic fever, chest x-ray abnormalities and clinical specimens detected mold. Divided into 3 groups, including the time of dissection and see no deep mycosis, respectively, 22 cases and 12 cases and 27 cases of undissected. Thirteen cases were treated with antimycotic drugs, and those with deep mycosis were found to be the control group. Anti-fungal drug treatment for intravenous continuous anti-mycotic drug for more than a week, the daily amount of amphotericin B (AMPH) 6mg or more, diclozolide (MCZ)> 400mg, fluconazole (FCZ)> 200mg, 37 cases of chronic leukemia, 12 cases of malignant lymphoma, 5 cases of multiple myeloma, 2 cases of aplastic anemia, the other 5 cases.