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我院自1984～1985年观察了21例乳房过早发育患儿的临床表现及血清LH、FSH和PRL水平,并与同年龄的正常儿童作了比较。临床资科对象:乳房过早发育患儿共21例,女性16例,男性5例,年龄1～8岁,其中1～4岁者占60%。根据病史,临床症状,体检,蝶鞍X线摄片,双侧肾上腺B型超声,24小时尿17-羟、17-酮和甲状腺功能检查,均排除了垂体、肾上腺、甲状腺和性腺病变。患儿无误服避孕药史。另9例3～7岁正常儿童作为对照组,其中女性6例,男性3例。临床表现:按Marchall等的青春期乳房发育分期法,患儿的乳房发育均处于第二期(B_2)和第三期(B_3)之间,即从乳芽形成至乳房和乳晕形成直径1.5～5.0 cm明
Our hospital from 1984 to 1985 observed 21 cases of premature breast development in children with clinical manifestations and serum levels of LH, FSH and PRL, and with the same age normal children were compared. Clinical data subjects: premature breast development in children with a total of 21 cases, 16 females, 5 males, aged 1 to 8 years, of which 1 to 4 years accounted for 60%. According to medical history, clinical symptoms, physical examination, sella radiography, bilateral adrenal B ultrasound, 24-hour urine 17-hydroxy, 17-keto and thyroid function tests, excluding pituitary, adrenal, thyroid and gonadal lesions. Children without any history of contraceptives. Another 9 cases of normal children aged 3 to 7 years as a control group, including 6 females and 3 males. Clinical manifestations: according to Marchall et al adolescent breast staging method, breast development in children are in the second phase (B_2) and the third phase (B_3), that is, from the formation of lactating buds to the formation of breast and areola diameter of 1.5 to 5.0 cm bright