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目的:探讨盐酸氨溴索与固尔苏治疗新生儿呼吸窘迫综合征临床疗效,为新生儿呼吸窘迫综合征提供更好的治疗方法。方法:选取该院2011年12月~2012年12月收治入院的经临床诊断为新生儿呼吸窘迫综合征患儿80例,随机分为两组,观察组使用固尔苏治疗基础上加用盐酸氨溴索进行治疗,对照组采用固尔苏治疗,观察两组患儿血气分析、机械通气参数以及肺部合并症、氧疗时间、住院时间等。结果:观察组患儿血气指标显著优于对照组,且观察组患儿使用盐酸氨溴索治疗后吸气峰压(PiP)、呼气末正压(PEEP)以及吸入氧浓度(FiO2)分别为(15.33±1.13)cmH2O、(3.21±0.51)cmH2O和(40.2±5.7)%,显著优于对照组。两组相比,差异具有统计学意义,P<0.05。观察组在氧疗时间(61±15)h及住院天数(13.6±6.4)天上明显低于对照组的(92±18)h和(19.2±7.8)天,差异具有统计学意义,P<0.05。观察组并发症发生率为2.5%明显低于对照组的15.0%,P<0.05。结论:采用固尔苏治疗基础上加用盐酸氨溴索进行治疗新生儿呼吸窘迫综合征能显著改善患儿血气和机械通气情况,且有效减少肺部感染等并发症的发生率,减少氧疗时间及住院费用,效果显著,值得推荐应用。
Objective: To investigate the clinical efficacy of ambroxol and glucocorticoids in the treatment of neonatal respiratory distress syndrome, and provide a better treatment for neonatal respiratory distress syndrome. Methods: Eighty children with neonatal respiratory distress syndrome admitted to our hospital from December 2011 to December 2012 were randomly divided into two groups. The observation group was given Glucocorticoid plus hydrochloric acid Ambroxol for treatment, the control group with Guer Su treatment, two groups of children were observed blood gas analysis, mechanical ventilation parameters and lung complications, oxygen therapy time, hospitalization time. Results: The blood gas index of the observation group was significantly better than that of the control group, and the peak pressure of PiP, PEEP and FiO2 were significantly lower in observation group after ambroxol hydrochloride treatment (15.33 ± 1.13) cmH2O, (3.21 ± 0.51) cmH2O and (40.2 ± 5.7)%, which were significantly better than those of the control group. Compared with the two groups, the difference was statistically significant, P <0.05. The observation group had significantly lower oxygen breathing time (61 ± 15) h and days of hospitalization (13.6 ± 6.4 days) than the control group (92 ± 18) h and (19.2 ± 7.8) days, the difference was statistically significant, P <0.05 . The complication rate in observation group was 2.5%, which was significantly lower than that in control group (15.0%, P <0.05). Conclusion: The treatment of neonatal respiratory distress syndrome with the addition of ambroxol on basis of ambroxol can significantly improve the blood gas and mechanical ventilation in children and reduce the incidence of complications such as pulmonary infection and reduce the incidence of oxygen therapy Time and hospital costs, the effect is significant, it is recommended application.