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为探讨新生儿缺氧缺血性脑病(HIE)血小板参数的变化及临床意义。对1t2例HIE患儿进行临床分度,于急性期进行血小板参数测定,并于恢复期复查,了解其动态变化情况。并以60例正常足月新生儿作为对照。(l)HIE患儿急性期血小板总数(PLT)较正常儿明显降低(P<0.01),平均血小板体积(MPV)和血小板体积分布宽度(PDW)较正常儿明显增高(P<0.01)。恢复期PLT、MPV、PDW与正常组之间无明显差异(P>0.05)。(2)HIE患儿PLT随HIE病情加重而降低(P<0.01)。而MPV、PDW则随病情加重而增大(P<0.01,P>0.05)。结果提示,动态观察HIE患儿血小板参数,可作为判断HIE病情严重程度的指标。
To investigate the changes and clinical significance of platelet parameters in neonatal hypoxic-ischemic encephalopathy (HIE). 1t2 cases of HIE in children with clinical indexing, platelet parameters in the acute phase determination, and review in the recovery period to understand the dynamic changes. 60 normal newborn infants as control. (l) PLT in children with HIE was significantly lower than that in normal children (P <0.01), mean platelet volume (MPV) and PDW were significantly higher than those in normal children (P <0.01). There was no significant difference between convalescent PLT, MPV, PDW and normal group (P> 0.05). (2) The PLT of HIE children decreased with the increase of HIE (P <0.01). However, MPV and PDW increased with the severity of illness (P <0.01, P> 0.05). The results suggest that dynamic observation of platelet parameters in children with HIE can be used as an indicator of the severity of HIE.