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目的:通过对孕中期母体血清标记物AFP(甲胎蛋白)和HCG(人绒毛膜促性腺激素)的水平监测,筛查唐氏综合征(DS)和神经管畸形(NTD)的高危人群和低危人群。方法:使用太原市中科恒业数码有限公司生产的胶体金免疫血清试剂引导卡,进行AFP和HCG的判读。结果:检查69例孕妇的血清AFP和HCG水平,发现DS阳性1例,NTD阳性1例。结论:监测孕中期母体血清标记物AFP和HCG,DS和NTD的检出率分别为75%～85%和85%～90%,该方法无创、灵敏度高及特异性较好,值得临床推广应用。
OBJECTIVE: To screen high-risk populations of Down’s syndrome (DS) and neural tube defects (NTD) by monitoring the levels of AFP (fetoprotein) and HCG (human chorionic gonadotropin) in the second trimester of pregnancy and Low-risk groups. Methods: Colloidal gold immune serum reagent guide cards produced by Taiyuan Zhongke Sunny Digital Co., Ltd. were used to interpret AFP and HCG. Results: The serum levels of AFP and HCG in 69 pregnant women were examined. One patient was positive for DS and one was positive for NTD. CONCLUSIONS: The detection rates of AFP, HCG, DS and NTD in the second trimester of pregnancy are 75% -85% and 85% -90%, respectively. This method is noninvasive, sensitive and specific and worthy of clinical application .