论文部分内容阅读
中性粒细胞肺内的大量浸润是急性肺损伤的主要病理特征之一,它能清除病原微生物等有害物质而发挥保护肺组织的作用,但若中性粒细胞大量的肺内浸润和过度的活化则可损伤肺组织,此负面作用在急性肺损伤的发生和发展中有重要的意义;磷酸肌醇-3激酶的信号转导途径在调节急性肺损伤患者中性粒细胞的细胞因子表达、呼吸爆发、趋化及凋亡有重要的作用。故了解其作用机制可能会从细胞分子水平为急性肺损伤的防治开辟新的途径。
Massive infiltration of neutrophils in the lungs is one of the main pathological features of acute lung injury, which can remove harmful substances such as pathogenic microorganisms and play a role in the protection of lung tissue, but if a large number of neutrophils in the lung infiltration and excessive Activation can damage the lung tissue, this negative effect in the occurrence and development of acute lung injury have important significance; phosphoinositide-3 kinase signal transduction pathway in the regulation of acute lung injury in patients with neutrophil cytokine expression, Respiratory burst, chemotaxis and apoptosis have an important role. Therefore, understanding its mechanism of action may open up new avenues for the prevention and treatment of acute lung injury at the cellular and molecular level.