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目的:探讨抗结核药所致药物性肝损害的发病规律、临床特点及高危因素。方法:对2008年1月至2011年12月我院收治的22例使用抗结核药导致药物性肝损害患者的临床资料进行回顾性分析。结果与结论:抗结核药导致肝损害的机制较复杂。在为结核病患者使用抗结核药进行治疗期间,应定期检测其肝功能,对其出现的药物性肝损伤做到早发现、早诊断、早治疗,以顺利地完成抗结核治疗。
Objective: To investigate the incidence of drug-induced liver damage caused by anti-TB drugs, clinical features and risk factors. Methods: The clinical data of 22 patients with drug-induced liver injury who were treated with antituberculosis drugs in our hospital from January 2008 to December 2011 were analyzed retrospectively. RESULTS AND CONCLUSION: The mechanism of anti-TB drugs leading to liver damage is more complicated. In the treatment of tuberculosis patients with anti-TB drugs should be regularly tested for liver function, drug-induced liver injury in its early detection, early diagnosis and early treatment in order to successfully complete the anti-TB treatment.