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贫腔内膜异位症常以大剂量孕激素或强效的17α-乙炔睾丸酮衍生物丹那唑治疗,后者对脂代谢有不利影响。但小剂量17α-羟孕酮衍生的孕激素(如甲孕酮)不降低血中高密度脂蛋白胆固醇(HDL-C)和HDL_2-C含量。本文中作者评价了较高剂量甲孕酮(MPA)对血浆脂蛋白的影响。研究包括10名组织学确证内膜异位症的妇女,除此症外体健,平均年龄38岁(26～42岁),研究前6个月内未用激素,于内膜异位症术后至少3个
Endometriosis is often treated with high-dose progestin or the potent 17α-ethynyl testosterone derivative, danazol, which adversely affects lipid metabolism. However, small doses of 17α-hydroxyprogesterone-derived progesterone (eg, medroxyprogesterone acetate) did not reduce HDL-C and HDL-C levels in the blood. In this article, the authors evaluated the effects of higher doses of MPA on plasma lipoproteins. The study included 10 women with histologically confirmed endometriosis, except for a healthy outside body with an average age of 38 years (range, 26-42 years). Hormone was not used within the first 6 months of the study and endometriosis After at least 3