论文部分内容阅读
目的探讨高危型人乳头瘤病毒(HPV)检测在宫颈病变筛查中的临床意义。方法对2003年10月至2005年1月在我院就诊的1476例患者进行超薄液基细胞学检查、高危型HPV检测及阴道镜检查。结果1476例患者中HPV感染阳性例数为654例,占44.31%,平均年龄为36.57岁;阴性例数为822例,占55.69%,平均年龄为36.48岁。高危型HPV感染阳性率随宫颈病变程度加重而明显升高。HPV高危型阳性患者中,病理诊断宫颈炎占35.7%(444/1244);宫颈上皮内瘤变(CIN)I级占84.3%(70/83);CINII级占90.0%(54/60);CINIII级占95.8%(69/72);早期浸润癌为100%(17/17)。结论在宫颈病变的早期筛查中,联合进行细胞学、高危型HPV-(第2代杂交捕获实验)HC2检测、阴道镜及病理学检查有重要意义。
Objective To investigate the clinical significance of high risk human papillomavirus (HPV) detection in cervical lesions screening. Methods A total of 1476 patients treated in our hospital from October 2003 to January 2005 underwent ultrathin liquid-based cytology, high-risk HPV testing and colposcopy. Results The number of positive cases of HPV infection in 1476 patients was 654 (44.31%) with an average age of 36.57 years. The number of negative cases was 822 (55.69%) with an average age of 36.48 years. High-risk HPV infection with the positive rate of cervical lesions increased significantly increased. Cervical inflammation accounted for 35.7% (444/1244), grade CIN 84.3% (70/83), and grade CINII 90.0% (54/60). CINIII grade accounted for 95.8% (69/72); early invasive carcinoma was 100% (17/17). Conclusion In the early screening of cervical lesions, combined with cytology, high-risk HPV- (second generation hybridization capture test) HC2 detection, colposcopy and pathological examination of great significance.