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AIM:To assess the possible effect of integrated traditionalChinese and Western medicine on severe acute respiratorysyndromes.METHODS:The current available randomized controlledtrials of integrated traditional Chinese and Western medicineon SARS were identified through systematically searchingliterature in any languages or any types of publications.Additional studies of gray literature were also collected.The quality of studies was evaluated by two investigatorsindependently based largely on the quality criteria specifiedCONSORT.Statistical analysis of the results was performedusing RevMan 4.2.0 software developed by the CochraneCollaboration,RESULTS:Six studies(n=366)fulfilling the indusion criteriawere found,of which the quality of one study was gradedas B,the remaining five were graded as C.Two studies wereperformed with meta-analysis,the other four studies existedsome heterogeneity for which meta-analysis could not beperformed,a significant effect on lung infiltrate absorptionwas found in the treatment groups of these two studies[RR 6.68,95% CI(2.93,15.24),P<0.01],there was nosignificant differences between the mortality [RR 0.86,95%CI(0.22,3.29),P=0.82] and the average dosage ofcorticosteroid [WMD-39.65,95% CI(-116.84,37.54),P=0.31].The other three studies also showed significantdifferences in infiltrate absorption,including national drugNo.2.3.4 in combination with Western medicine [RR 5.45,95% CI(1.54,19.26)],compound formulas NO.1 combinedwith Western medicine [WMD 0.24,95% CI(0.02,0.46)],compound formulas combined with Western medicine [RR8.06,95% CI(0.40,163.21)].Kangfeidian No.4 in combinationwith Western medicine had no significant effect on symptomimprovement such as loss of dyspnea and cough[RR 1.50,95%CI(0.41,5.43)] and [RR 1.29,95%CI(0.30,5.43)].CONCLUSION:Integrated traditional Chinese and Westernmedicines has some positive effects on lung infiltrate absorptionin SAPS patients,and is recommended as an adjunct treatment for SAPS.However,its effect on SAPS requires further carefulstudy due to limited available randomized control trials.
AIM: To assess the possible effect of integrated traditional Chinese and Western medicine on severe acute respiratorysyndromes. METHODS: The current available randomized controlled trials of integrated traditional Chinese and Western medicineon SARS were identified through systematically searching literatures in any languages or any types of publications. Additional studies of gray literature were also collected by the quality of studies was evaluated by two investigators in dependent basis based on the quality criteria specifiedCONSORT.Statistical analysis of the results was performed using RevMan 4.2.0 software developed by the Cochrane Collaboration, RESULTS: Six studies (n = 366) fulfilling the industion criteriawere found, of which the quality of one study was gradedas B, the remaining five were graded as C.Two studies wereperformed with meta-analysis, the other four studies existed heterogeneity for which meta-analysis could not beperformed, a significant effect on lung infiltrate absorptionwas fo und for the treatment groups of these two studies [RR 6.68, 95% CI (2.93, 15.24), P <0.01], there was nosignificant differences between the mortality [RR 0.86,95% CI (0.22,3.29) ] and the average dosage of corticosteroid [WMD-39.65,95% CI (-116.84,37.54), P = 0.31] .the other three studies also showed significant differences in infiltrationrate absorption, including national drug No. 2.3.4 in combination with Western medicine [ Compound formulas NO.1 combined with Western medicine [WMD 0.24, 95% CI (0.02, 0.46)], compound formulas combined with Western medicine [RR8.06, 95% CI 0.40, 163.21)]. Kangfeidian No.4 in combination with Western medicine had no significant effect on symptom impromptu such as loss of dyspnea and cough [RR 1.50, 95% CI (0.41, 5.43)] and [RR 1.29, 95% CI , 5.43)]. CONCLUSION: Integrated traditional Chinese and Westernmedicines has some positive effects on lung infiltrate absorption in SAPS patients, and is recommended as an adjunct treatment for SAPS. However, its effect onSAPS requires further careful troubleshooting due to limited available randomized control trials.