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了解近期我院新生儿科败血症主要病原菌及其耐药情况 ,以期减少临床上应用抗生素的盲目性 ,降低耐药菌的产生。对 1 998年 6月 1 999年 1 2月入住我院新生儿科临床诊断败血症的 70例患儿 ,总共血培养出细菌 77株。用VITEK AMS鉴定菌株种属 ,K B法作抗生素耐药试验 ,根据NCCLS标准判断结果。凝固酶阴性葡萄球菌 ( 39株 )及金黄色葡萄球菌 ( 2 1株 )为主要致病菌 ,几乎全部对青霉素耐药 ,对红霉素及苯唑青霉素耐药率均超过 75% ,对万古霉素及环丙氟哌酸高度敏感。尚未发现耐万古霉素的葡萄球菌株及肠球菌株。几种杆菌 (大肠埃希菌 6株、肺炎克雷伯杆菌3株等 )对氨苄青霉素及庆大霉素耐药 ,对阿米卡星及第三代头孢霉素敏感。未测出ESBLs。本组资料显示绝大部分病例为非院内感染。
To understand the recent hospital neonatal sepsis major pathogens and their resistance, with a view to reducing the blindness of clinical application of antibiotics and reduce the generation of resistant bacteria. Seventy children with clinical diagnosis of sepsis in neonatology in our hospital from January 1998 to January 1999 were enrolled. A total of 77 bacteria were cultured in blood. VITEK AMS strains were used to identify strains, K B method for antibiotic resistance test, according to NCCLS criteria to determine the results. Staphylococcus aureus (39 strains) and Staphylococcus aureus (21 strains) were the main pathogens, almost all of them were resistant to penicillin, and the rates of resistance to erythromycin and oxacillin were over 75% Ciclopirox and Ciprofloxacin are highly sensitive. Vancomycin-resistant staphylococcal and enterococcal strains have not been found. Several bacilli (Escherichia coli 6, Klebsiella pneumoniae 3, etc.) resistant to ampicillin and gentamicin, amikacin and the third generation of cephalosporin sensitive. No ESBLs were detected. This group of data show that most cases of non-nosocomial infections.