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微悬臂生物传感器是基于原子力显微镜和生物传感器发展而来,具有无需标记、快速、实时、灵敏度高等优点,已广泛运用于生物医学、环境监测、医药、食品及军事等多个领域。微悬臂生物传感器已成为当前研究热点。本文对近年来微悬臂生物传感器的研究工作进行了综述,总结了微悬臂传感器中微悬臂梁的结构、工作模式、激励方法和检测方法。国内有关微悬臂传感器的综述多是着重于介绍微悬臂传感器的应用进展,而缺少对微悬臂传感器的检测方法或读出方式做全面而系统的介绍,本文不仅全面且系统地对微悬臂传感器的8种检测方法进行了详细的介绍和分析,还介绍了微悬臂梁的多种典型尺寸、外观和微悬臂传感器工作模式中的“热模式”。针对微悬臂传感器实现特定检测及提高灵敏度的目的,本文总结了微悬臂传感器的表面修饰方法,不仅介绍了国内外微悬臂生物传感器最新的应用动态,还介绍了一种具有自驱动自传感功能的新型微悬臂传感器,并对微悬臂生物传感器的应用前景作了探讨。
Micro-cantilever biosensors are based on atomic force microscopy and biosensors. They are widely used in many fields such as biomedicine, environmental monitoring, medicine, food and military because of their advantages of no marking, fast, real-time and high sensitivity. Micro-cantilever biosensor has become the current research hotspot. In this paper, we reviewed the research work of micro-cantilever biosensors in recent years, and summarized the structure, working mode, excitation and detection methods of micro-cantilever in micro-cantilever sensors. The review of micro-cantilever sensors in our country mainly focuses on the application of micro-cantilever sensors. However, there is a lack of comprehensive and systematic introduction of micro-cantilever sensor detection methods or reading methods. This paper not only comprehensively and systematically introduces micro-cantilever sensors 8 kinds of detection methods were introduced and analyzed in detail, and also introduced a variety of typical micro-cantilever dimensions, appearance and micro-cantilever sensor operating mode “hot mode ”. For the purpose of micro-cantilever sensor to achieve specific detection and improve the sensitivity, this paper summarizes the micro-cantilever sensor surface modification method, not only introduces the latest application of micro-cantilever biosensors at home and abroad, but also introduced a self-driven self-sensing function The new micro-cantilever sensor, and micro-cantilever biosensor application prospects were discussed.