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5-羟色胺(5-HT)在缺氧性肺缩管反应(Hy-poxic Pulmonary Vasoconstriction,HPV) 发生中的作用早被提出,但急性缺氧时体内5-HT的变化,及肺血管内皮代谢循环血中5-HT功能的变化,报道较少。对此,本实验作了初步探讨。 一、材料与方法 雄性Wistar大鼠16只,体重351±33克。在乌拉坦全麻下,插入颈动脉与肺动脉导管,以测量体动脉压和肺动脉压。用人工呼吸机维持通气。测定动脉血氧分压(PaO_2)、二氧化碳分压(PaCO_2)及
The role of serotonin (5-HT) in the pathogenesis of hypoxic pulmonary vasoconstriction (HPV) has long been proposed, but the changes of 5-HT in acute hypoxia and the changes of pulmonary vascular endothelium metabolism Changes in circulating 5-HT function, less reported. In this regard, this experiment made a preliminary discussion. First, materials and methods Male Wistar rats 16, weighing 351 ± 33 grams. Under urethane anesthesia, carotid and pulmonary catheters were inserted to measure body and pulmonary arterial pressure. Use a ventilator to maintain ventilation. The arterial partial pressure of oxygen (PaO_2) and the partial pressure of carbon dioxide (PaCO_2) were measured