论文部分内容阅读
目的探讨妊娠糖尿病(GDM)孕妇与正常孕妇骨代谢特点的异同。方法比较67例妊娠糖尿病患者(GDM组)与13例正常糖耐量孕妇(NGT组)血钙、磷、ALP、25OHD、CTx、24h尿钙、跟骨超声(SOS)等骨代谢指标的异同。然后将GDM组患者分为A、B两组,分别给予低、高两种不同剂量钙和维生素D干预至分娩前,比较两组治疗前后上述指标的差异。结果 GDM组血钙、磷为(2.3±0.1)mmol/L、(1.3±0.2)mmol/L,NGT组血钙、磷分别为(2.2±0.1)mmol/L,(1.1±0.1)mmol/L(P<0.05);GDM组和NGT组24h尿钙均升高;GDM B组24h尿钙治疗前为(11.0±-6.9)mmol/L,治疗后为(8.2±4.3)mmol/L,明显下降(P<0.05)。结论 GDM孕妇骨代谢特点和NGT孕妇基本相同,24h尿钙均显著增加。GDM可能导致血钙、磷轻度增加。补充足量的钙剂和维生素D可使尿钙丢失减少。
Objective To explore the similarities and differences of bone metabolism in pregnant women with gestational diabetes mellitus (GDM) and normal pregnant women. Methods The similarities and differences of bone metabolism indexes such as calcium, phosphorus, ALP, 25OHD, CTx, 24 h urinary calcium and calcaneal ultrasound (SOS) between 67 gestational diabetes mellitus patients (GDM group) and 13 normal glucose tolerance pregnant women (NGT group) were compared. Then the patients in GDM group were divided into A and B groups, and were given low and high doses of calcium and vitamin D respectively before intervention. Before and after treatment, the above indexes were compared. Results The levels of serum Ca and P were (2.3 ± 0.1) mmol / L and (1.3 ± 0.2) mmol / L respectively in NGDM group and (2.2 ± 0.1) mmol / L and (1.1 ± 0.1) mmol / L (P <0.05). The levels of urinary calcium in both GDM group and NGT group were significantly higher than those in the control group (P <0.05). The levels of urinary calcium in GDM group and NGT group were (11.0 ± 6.9) mmol / L before treatment and (8.2 ± 4.3) Decreased significantly (P <0.05). Conclusion The features of bone metabolism in GDM pregnant women are basically the same as that of NGT pregnant women, and the levels of urinary calcium in 24 hours are significantly increased. GDM may lead to mild increases in serum calcium and phosphorus. Supplementary adequate calcium and vitamin D can reduce the loss of urinary calcium.