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三邻甲苯基磷酸酯(TOCP)属有机磷酸酯类化合物,剧毒,具有多器官毒性,主要表现在神经系统、睾丸、肝脏和免疫系统;其中以神经系统为主要靶组织,以产生迟发性神经毒性(OPIDN)为特征,造成机体永久性损伤。TOCP中毒没有特效药治疗,禁用和限量为主要预防措施。全面了解TOCP毒性作用,有助于对机制的进一步研究,为临床治疗TOCP中毒患者提供参考,对其他有机磷毒物研究有重要借鉴意义。
Tri-o-tolyl phosphate (TOCP) is an organophosphate compound that is highly toxic and has multiple organ toxicity. It is mainly expressed in the nervous system, testis, liver and immune system. The nervous system is the main target tissue to produce delayed Sexual neurotoxicity (OPIDN) is characterized by permanent damage to the body. TOCP poisoning is not a cure, disable and limit as the main preventive measures. A comprehensive understanding of the toxic effects of TOCP helps to further study the mechanism for the clinical treatment of TOCP poisoning provide a reference for other studies on organophosphate poisons have important referential significance.