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目的探讨新生儿缺血缺氧性脑病(HIE)患儿血清酶的变化及其与新生儿缺血缺氧性脑病(HIE)的发生,严重程度预后的相关性。方法测定70例HIE新生儿和22例正常足月新生儿的血清酶。结果 HIE组血清酶水平均明显高于正常对照组(P<0.05),且以重度HIE组更甚。结论 HIE患儿存在血清酶升高,因此,急性期HIE患儿血清酶水平变化是辅助诊断HIE及协助HIE临床分度及判断预后的重要指标。
Objective To investigate the changes of serum enzymes in neonates with hypoxic-ischemic encephalopathy (HIE) and its relationship with the occurrence and severity of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Serum enzyme levels were measured in 70 HIE neonates and 22 normal term neonates. Results The levels of serum enzymes in HIE group were significantly higher than those in normal control group (P <0.05), and worse in severe HIE group. Conclusions There is elevated serum enzyme in children with HIE. Therefore, the change of serum enzyme level in children with HIE in the acute phase is an important index for assisting the diagnosis of HIE and assisting the clinical grade of HIE and prognosis.