【摘 要】
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Primary cilium, which protrudes from the cell, is a microtubule-based structure ensheathed by a highly specialized plasma membrane (PM).It serves as a signaling
【机 构】
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Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072,
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Primary cilium, which protrudes from the cell, is a microtubule-based structure ensheathed by a highly specialized plasma membrane (PM).It serves as a signaling hub for sensing and transducing various external stimuli including fluids, light, odorants as well as extracellular molecules.Of various signal transduction pathways that act through the primary cilium, the Hedgehog (Hh) pathway draws the most attention owing to its essential role in vertebrate development and its intimate link to carcinogenesis (Bangs and Anderson, 2017).The major components of the Hh pathway include the secreted ligand Hh, two transmembrane proteins Patched (Ptch) and Smoothened (Smo), and the transcription factor glioma-associated oncogene (Gli).Ptch is the receptor for Hh which, in the absence of Hh, resides at the primary cilium and prevents ciliary localization and activation of Smo.Upon Hh binding, however, Ptch is suppressed and displaced from the ciliary membrane.This permits Smo to enter the primary cilium and initiate a cascade of events that lead to the activation of Gli transcription factors and transcription of downstream target genes.
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