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目的探讨孕中期产前筛查唐氏综合征的临床意义。方法采用时间分辨荧光法,对863例孕中期孕妇血清进行AFP和β-hCG两项指标浓度的检测,结合孕妇年龄,体重,孕周等因素,配套软件分析胎儿患唐氏儿的风险率。结果 863例中,唐氏高风险51例,筛查阳性率5.9%,开放性神经管缺陷高危4例,阳性率0.4%。结论孕中期母体血清标记物联合检测是预防唐氏儿出生的重要途径,对降低出生缺陷具有重要作用。
Objective To investigate the clinical significance of prenatal screening Down’s syndrome in the second trimester of pregnancy. Methods Time-resolved fluorescence was used to detect serum concentrations of AFP and β-hCG in 863 pregnant women of the second trimester. The age, weight, gestational age and other factors of pregnant women were used to analyze the risk of fetus with Down’s syndrome. Results In 863 cases, Down’s high risk was 51 cases, screening positive rate was 5.9%, and high risk of open neural tube defects was found in 4 cases, the positive rate was 0.4%. Conclusion The combined detection of maternal serum markers in the second trimester is an important way to prevent Down’s birth and plays an important role in reducing birth defects.