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红霉素是碱性药物,主要与血中α_1酸性蛋白结合,在肝脏代谢后排泄到体外。首先,在肝硬变患者的血清中,α_1酸性蛋白减少、其结果使血中游离型红霉素的量所占比值上升。此结论已经体外试验证实。本文研究了肝硬变患者中红霉素的药代动力学。在5名酒精性肝硬变患者和6名健康人中、各静滴500mg红霉素进行试验,研究红霉素的药代动力学。血清中α_1酸性蛋白浓度:肝硬变患者为4.7±2.4μmol/L;健康人为10.3±2.1μmol/L。结果,血清中红霉素游离型所占比值(fu):肝硬变患者为58.3±17.7%;健康人为30.5±2.8%。fu值与α
Erythromycin is a basic drug, mainly with blood α_1 acidic protein, excreted in the liver after metabolism. First, in patients with cirrhosis of the serum, α 1 acidic protein decreased, resulting in the amount of free erythromycin in the blood ratio increased. This conclusion has been confirmed in vitro experiments. This article studies the pharmacokinetics of erythromycin in patients with cirrhosis. In five patients with alcoholic cirrhosis and six healthy individuals, 500 mg of erythromycin was intravenously administered to study the pharmacokinetics of erythromycin. Serum alpha 1 acidic protein concentrations: 4.7 ± 2.4 μmol / L for patients with cirrhosis and 10.3 ± 2.1 μmol / L for healthy subjects. As a result, the percentage of free erythromycin in serum (fu) was 58.3 ± 17.7% in cirrhotic patients and 30.5 ± 2.8% in healthy subjects. fu value and α