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目的:对干扰素α-2b治疗乙型肝炎的临床效果进行观察和探讨。方法:选择100例于2012年2月至2013年6月间在我院进行乙型肝炎治疗的患者资料进行研究和分析,将患者分为对照组和治疗组两组,每组各有50例患者,对全部患者进行常规治疗,在此基础上对治疗组患者进行干扰素α-2b治疗,比较和分析两组患者的治疗效果。结果:对照组TBIL、AST、ALT恢复正常患者分别为32例、27例和17例,治疗组分别为45例、44例和38例,两组患者肝功能差异具有统计学意义(P<0.05)。对照组HBV-DNA、抗Hbe转阴、HbsAg转阴患者分别为20例、12例和1例,治疗组分别为44例、24例和23例,两组患者乙肝病毒指标变化差异具有统计学意义(P<0.05)。对照组1例患者出现不良反应,占2%,治疗组2例患者出现不良反应,占4%,两组患者不良反应发生率差异具有统计学意义(P<0.05)。结论:将干扰素α-2b用于乙型肝炎治疗中能够取得理想的治疗效果,值得被推广和应用到临床治疗中。
Objective: To observe and discuss the clinical effect of interferon α-2b in the treatment of hepatitis B Methods: 100 patients who underwent hepatitis B in our hospital from February 2012 to June 2013 were selected to study and analyze the data. The patients were divided into control group and treatment group, with 50 patients in each group Patients, all patients routine treatment, on the basis of the treatment group of patients with interferon α-2b treatment, comparison and analysis of the treatment effect of two groups of patients. Results: There were 32 cases, 27 cases and 17 cases of normal control group, respectively. The treatment group were 45 cases, 44 cases and 38 cases respectively. The difference of liver function between the two groups was statistically significant (P <0.05 ). In the control group, HBV-DNA, anti-HBe negative, HbsAg negative patients were 20 cases, 12 cases and 1 case, the treatment group were 44 cases, 24 cases and 23 cases, two groups of patients with hepatitis B virus changes were statistically significant Significance (P <0.05). One patient in the control group had adverse reactions, accounting for 2%. Two patients in the treatment group had adverse reactions, accounting for 4%. The difference in adverse reactions between the two groups was statistically significant (P <0.05). Conclusion: The interferon α-2b can be used in the treatment of hepatitis B to achieve the desired therapeutic effect, which deserves to be popularized and applied to the clinical treatment.