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过去认为,卵巢是用来控制着床前各现象和着床时所需要的雌激素和孕酮的唯一来源。近来发现,除卵巢外,还可能有第二个来源,那就是着床前的胚胎。因此,在生殖生物学中提出了一个新的设想。即着床前的胚胎能合成甾体激素,后者主要调节下列现象:①桑葚胚和胚泡的某些尚未阐明的代谢活动;②由桑葚胚到胚泡的转变;③透明带的脱落和溶解;④胚泡的着床。作者用确定了的组织化学方法,用大鼠等动物,研究了着床前和着床后早期胚泡的△~5—3β羟化甾体脱氢酶(3β—HSD)的活性。这种酶是甾体生成的一个关键性的酶,它的存在就说明能合成甾体激素。
In the past, ovaries were the sole source of estrogen and progesterone required to control pre-implantation phenomena and implantation. Recently found, in addition to the ovaries, there may be a second source, that is pre-implantation embryos. Therefore, a new idea has been put forward in reproductive biology. That pre-implantation embryos can synthesize steroid hormones, which mainly regulate the following phenomena: ① morula and blastocyst some unexplained metabolic activity; ② from the morula to blastocyst transformation; ③ zona pellucida and Dissolved; ④ blastocyst implantation. Using established histochemical methods, the authors studied the activity of △ 5-3β hydroxy-steroidal dehydrogenase (3β-HSD) in pre-implantation and post-implantation early blastocysts using rat and other animals. This enzyme is a key enzyme in steroidogenesis and its presence suggests the ability to synthesize steroid hormones.