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目的探讨上皮细胞膜蛋白1(EMP1)在鼻腔鼻窦内翻性乳头状瘤中的表达及其在疾病发生中的意义。方法采用免疫组化和Quantitative PCR分别在25例鼻腔鼻窦内翻性乳头状瘤和15例正常下鼻甲黏膜标本中测定EMP1的表达。结果在鼻腔鼻窦内翻性乳头状瘤组织中,中度上皮化生(12/25,48%)是最常见的上皮重塑类型。与对照组相比,EMP1的蛋白及mRNA水平均有明显的降低。此外,EMP1的表达水平与上皮化生的严重程度呈负相关性。结论在鼻腔鼻窦内翻性乳头状瘤中,EMP1表达的下调与上皮化生的严重程度相关,可作为评估鼻腔鼻窦内翻性乳头状瘤上皮异常重塑的一个生物指标。
Objective To investigate the expression of epithelial cell membrane protein 1 (EMP1) in inverted papilloma of nasal sinus and its significance in the pathogenesis. Methods Immunohistochemistry and Quantitative PCR were used to determine the expression of EMP1 in 25 cases of nasal inverted papilloma and 15 cases of normal inferior turbinate mucosa. Results In the nasal sinus inverted papilloma tissue, moderate epithelial metaplasia (12/25, 48%) is the most common type of epithelial remodeling. Compared with the control group, EMP1 protein and mRNA levels were significantly reduced. In addition, the expression level of EMP1 was negatively correlated with the severity of epithelial metaplasia. Conclusion The down-regulation of EMP1 expression in inverted papilloma of nasal sinuses is related to the severity of epithelial metaplasia and may be used as a biomarker for the evaluation of abnormal epithelial remodeling of inverted papilloma in nasal sinuses.