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21-氨基类固醇(u-74389G)是对氧自由基诱发的和铁催化的类脂过氧化作用的强力抑制剂,也是一非糖类皮质激素,它可减轻内毒素性休克鼠的肝损害,抑制肝内核因子-κB激活而延长其生存时间。作者进行实验研究以观察21-氨基类固醇能否通过抑制肝枯否细胞的核因子(NF)-κB激活而阻止前
21-Aminostat (u-74389G) is a potent inhibitor of oxygen radical-induced and iron-catalyzed lipid peroxidation and a non-glucocorticoid which reduces liver damage in endotoxic shock mice, Inhibit the activation of hepatic nuclear factor-κB and prolong its survival time. The authors conducted an experimental study to see if 21-amino steroids could prevent pre-blockage by inhibiting nuclear factor (NF) -κB activation in Hepkat cells